Your Methylation Gene Results (Explained)

1. MTHFR (most important one)
rs1801133 (C677T): GG → Normal
rs1801131 (A1298C): GT → Mild variant (heterozygous)

What this means:
Your main MTHFR function is largely normal
You have a mild reduction in efficiency from A1298C

Translation:
Your body can process folate pretty well, just not perfectly under stress.

Usually no major issues

You may benefit slightly from good folate intake (leafy greens)

2. COMT (dopamine & stress response)
rs4680: AG → Intermediate (normal-ish)

What this means:
You break down dopamine at a balanced speed

Translation:
You likely have a moderate stress response—not overly sensitive, not overly numb.

Good emotional balance overall

Can handle stress reasonably well

3. CBS (detox pathway)
rs234706: GG → Normal
rs1801181: AG → Mild variant

What this means:
Mostly normal sulfur/detox processing
Slight variation, but nothing major

Translation:
Your detox system works fine, with maybe small variation.

No strong sulfur sensitivity expected

No major detox issues indicated

4. MTR (B12 processing)
rs1805087: AA → Normal

What this means:
Your B12 recycling pathway works well

Translation:
Your body handles B12 efficiently.

Good for energy and methylation cycle

5. MTRR (B12 regeneration)
rs1801394: GG → Normal

What this means:
Your body can regenerate B12 properly

Translation:
Your methylation cycle support system is solid.

6. MAOA (not found in your file)
No data detected for this SNP

This is normal—some tests don’t include it.

Overall Methylation Profile (Your Big Picture)

Good news:
You have a strong, mostly normal methylation system
No major MTHFR mutation
Good B12 processing (MTR/MTRR)
Balanced neurotransmitter handling (COMT)

Your only notable trait:
Mild MTHFR A1298C variant

Real-world meaning:
Slightly less efficient under:
Poor diet
High stress
Low nutrient intake
But:
This is very common and usually NOT a problem

What you DO NOT need to worry about
You do NOT have a severe MTHFR mutation
You do NOT have major methylation impairment
You likely do NOT need heavy supplementation